| Date | Location | Result | Â |
| Oct 29, 2010   | Orlando, Fla.   | UCF 6, Southern Miss 0   | Box score  |
| Oct 24, 2010   | Hattiesburg, Miss.   | Tulsa 4, Southern Miss 1   | Box score  |
| Oct 22, 2010   | Hattiesburg, Miss.   | SMU 3, Southern Miss 1   | Box score  |
| Oct 17, 2010   | Colorado Springs, CO   | Colorado College 2, Southern Miss 0   | Box score  |
| Oct 15, 2010   | El Paso, Texas   | UTEP 2, Southern Miss 0   | Box score  |
| Oct 10, 2010   | Hattiesburg, Miss   | Houston 1, Southern Miss 1   | Box score  |
| Oct 08, 2010   | Hattiesburg, Miss.   | RICE 2, Southern Miss 0   | Box score  |
| Oct 03, 2010   | Memphis, Tenn.   | Memphis 2, Southern Miss 0   | Box score  |
| Oct 01, 2010   | Birmingham, Ala.   | UAB 6, Southern Miss 0   | Box score  |
| Sep 26, 2010   | Hattiesburg, Miss.   | East Carolina 4, Southern Miss 1   | Box score  |
| Sep 24, 2010   | Hattiesburg, Miss   | Marshall 1, Southern Miss 0   | Box score  |
| Sep 19, 2010   | Hattiesburg, Miss.   | Southern Miss 2, Northwestern State 0   | Box score  |
| Sep 17, 2010   | Oxford, Miss.   | Ole Miss 3, Southern Miss 0   | Box score  |
| Sep 12, 2010   | Hattiesburg, Miss.   | Southern Miss 6, Jackson State 0   | Box score  |
| Sep 08, 2010   | Hammond, La.   | Southern Miss 1, Southeastern La. 1   | Box score  |
| Sep 05, 2010   | Nashville, Tenn.   | Vanderbilt 2, Southern Miss 0   | Box score  |
| Sep 03, 2010   | Birmingham, Ala.   | Samford 4, Southern Miss 0   | Box score  |
| Aug 29, 2010   | Starkville, Miss.   | Miss. State 3, Southern Miss 0   | Box score  |
| Aug 27, 2010   | Hattiesburg, Miss.   | Southern Miss 4, Miss. Valley 0   | Box score  |
