University of Southern Mississippi Athletics
2021-22 MBB Game Notes
2021-22 Game Notes
| Game | Southern Miss Notes | Opponent Notes |
| William Carey | Southern Miss Notes  | William Carey Notes |
| Louisiana | Southern Miss Notes | Louisiana Notes |
| at TCU | Southern Miss Notes | TCU Notes |
| Lamar | Southern Miss Notes | Lamar Notes |
| UNC Wilmington | Southern Miss Notes | UNC Wilmington Notes |
| UC San Diego | Southern Miss Notes | UC San Diego Notes |
| at Montana | Southern Miss Notes | Montana Notes |
| at South Alabama | Southern Miss Notes | South Alabama Notes |
| at Southern Illinois | ||
| Loyola New Orleans | ||
| Jacksonville | ||
| at ULM | ||
| at ECU | ||
| WKU | ||
| Marshall | ||
| at UTSA | ||
| at UTEP | ||
| at LA Tech | ||
| LA Tech | ||
| at Middle Tennessee | ||
| North Texas | ||
| Rice | ||
| at FIU | ||
| at FAU | ||
| at UAB | ||
| UTSA | ||
| UTEP | ||
| at North Texas | ||
| at Rice | ||
| UAB | ||
| Charlotte | ||
| C-USA Championships |